Spatial regulation of cell signaling

Information processing through kinases, referred to as cell signaling, is key for how cells sense and respond to their local environment, including events occurring inside and outside of cells.

Once a signal is received, kinases work at distinct locations to reprogram cell function, including metabolism and gene expression. How are kinases regulated at specific cellular locations for efficient and accurate regulation of cell function? What does this localized activity mean for the cell?

To answer these questions, the Schmitt Lab develops and uses genetically encoded kinase activity reporters for kinases important for cell function like AMP activated protein kinase (AMPK) and PINK1. We use these reporters to study localized kinase activity and uncover new mechanisms for the regulation of cellular metabolism and function in healthy cells and in disease states, like cancer and neurodegeneration. Check out our recent publications to learn more.